Abstract #1412

Maternal Obesity Affects Offspring’s Brain Resting-State Functional Connectivity

Xuehua Li^1,2, Yilu Zhang², Aline Andres¹, R.T. Pivik¹, Charles Glasier², Raghu Ramakrishnaiah², Thomas Badger¹, and Xiawei Ou^1,2,3

¹Arkansas Children's Nutrition Center, Little Rock, AR, United States, ²Radiology, University of Arkansas for Medical Sciences, Little Rock, AR, United States, ³Arkansas Children's Hospital Research Institute, Little Rock, AR, United States

Recent studies have reported negative associations between maternal obesity during pregnancy and cognitive/neurodevelopmental outcome of children. It is speculated that neuro-programming differs in offspring of obese and normal weight women. In this study, we evaluated and compared the resting-state functional connectivity in 2-week-old infants born to normal weight or obese mothers, and we observed significant differences in brain connectivity associated with maternal obesity.

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