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Abstract #1413

Preliminary evaluation of altered brain microstructural in the emotion-cognitive region of children with hemophilia A: a diffusional kurtosis imaging study

Di Hu1, Ningning Zhang1, Huiying Kang1, Xiaolu Tang1, Yanqiu Lv1, Kaining Shi2, and Yun Peng1

1Beijing Children's hospital, Beijing, China, People's Republic of, 2Imaging Systems Clinical Science of Philips Healthcare, Beijing, China, People's Republic of

Our study is the first to evaluate relationship between emotion disorders and cognitive change in microstructure with hemophilia A, suggesting that the assessment of non-Gaussian directional diffusion using DKI provides more sensitive information about tissue microstructural changes than conventional image method and traditional psychological test.

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