Abstract #1413

Preliminary evaluation of altered brain microstructural in the emotion-cognitive region of children with hemophilia A: a diffusional kurtosis imaging study

Di Hu¹, Ningning Zhang¹, Huiying Kang¹, Xiaolu Tang¹, Yanqiu Lv¹, Kaining Shi², and Yun Peng¹

¹Beijing Children's hospital, Beijing, China, People's Republic of, ²Imaging Systems Clinical Science of Philips Healthcare, Beijing, China, People's Republic of

Our study is the first to evaluate relationship between emotion disorders and cognitive change in microstructure with hemophilia A, suggesting that the assessment of non-Gaussian directional diffusion using DKI provides more sensitive information about tissue microstructural changes than conventional image method and traditional psychological test.

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