Abstract #1414

BRAIN METABOLITE DIFFERENCES IN ONE-YEAR-OLD PRETERM INFANTS WITH INTRAUTERINE GROWTH RESTRICTION: ASSOCIATION WITH STRUCTURAL CHANGES AND NEURODEVELOPMENTAL OUTCOME

Rui Vasco Simoes^1,2,3, Emma Muñoz-Moreno⁴, Nuria Bargallo^5,6, Magdalena Sanz-Cortes⁷, and Eduard Gratacos^1,2,3

¹Fetal Medicine Research Center, BCNatal (Hospital Clinic and Hospital Sant Joan de Deu), Barcelona, Spain, ²Fetal Medicine Research Center, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ³Center for Biomedical Research on Rare Diseases (CIBER-ER), Barcelona, Spain, ⁴Experimental MRI 7T Unit, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁵Medical Image platform, Institut d’Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, ⁶Dept. Radiology, Hospital Clinic, Barcelona, Spain, ⁷Dept. Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States

It is difficult to address the differential effects of Intrauterine growth restriction (IUGR) and prematurity, as they represent two independent problems occurring simultaneously and can both contribute to impaired neurodevelopment. We have studied one-year-old preterm-IUGR infants and preterm and term appropriate for gestational age (AGA) infants, by MRI/MRS at 3T. Preterm-IUGR infants present metabolite profile changes in the frontal lobe, which are associated with brain structural and biophysical alterations, and poorer neurodevelopmental outcome at two years.

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