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Abstract #1424

ASL derived CBF Post Carotid Intervention Predicts Post-Operative Cognitive Impairment

Salil Soman1, Weiying Dai2, Elizabeth Hitchner3,4, Payam Massaband5,6, David Alsop1, Allyson C Rosen7,8, and Wei Zhou3,9

1Radiology, Harvard Medical School / BIDMC, Boston, MA, United States, 2Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, 3Vascular Surgery, Stanford University, Stanford, CA, United States, 4Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 5Radiology, Stanford University, Stanford, CA, United States, 6Radiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 7Psychology, Stanford University, Stanford, CA, United States, 8Psychology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, 9Vascular Surgery, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States

Carotid stenosis significantly increases the risk for stroke. Carotid revascularization surgeries have been shown to reduce this risk, but can also be associated with cognitive impairment that is not clearly linked to cardiovascular risk factors or perioperative complications. We performed baseline, 24 hours and 6 month post-surgery ASL brain CBF imaging, with baseline and 1 month post-operative neuropsychological testing to evaluate if CBF change patterns can predict cognitive impairment post-surgery. We found patterns of CBF change from baseline to 24 hours and 6 months post-surgery that predict decline in verbal learning and memory at 1 month.

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