Abstract #1424

ASL derived CBF Post Carotid Intervention Predicts Post-Operative Cognitive Impairment

Salil Soman¹, Weiying Dai², Elizabeth Hitchner^3,4, Payam Massaband^5,6, David Alsop¹, Allyson C Rosen^7,8, and Wei Zhou^3,9

¹Radiology, Harvard Medical School / BIDMC, Boston, MA, United States, ²Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ³Vascular Surgery, Stanford University, Stanford, CA, United States, ⁴Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, ⁵Radiology, Stanford University, Stanford, CA, United States, ⁶Radiology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, ⁷Psychology, Stanford University, Stanford, CA, United States, ⁸Psychology, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States, ⁹Vascular Surgery, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, United States

Carotid stenosis significantly increases the risk for stroke. Carotid revascularization surgeries have been shown to reduce this risk, but can also be associated with cognitive impairment that is not clearly linked to cardiovascular risk factors or perioperative complications. We performed baseline, 24 hours and 6 month post-surgery ASL brain CBF imaging, with baseline and 1 month post-operative neuropsychological testing to evaluate if CBF change patterns can predict cognitive impairment post-surgery. We found patterns of CBF change from baseline to 24 hours and 6 months post-surgery that predict decline in verbal learning and memory at 1 month.

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