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Abstract #1427

Altered baseline cerebral blood flow and neurotransmitter levels in episodic and chronic migraine

Lars Michels1, Franz Riederer2,3, Jeanette Villanueva1, Andreas Gantenbein4, Peter Sandor4, Roger Luechinger5, Martin Wilson6, and Spyros Kollias1

1University Hospital Zurich, Zurich, Switzerland, 2Neurological Center Rosenhuegel and Karl Landsteiner Institute for Epilepsy Research and Cognitive Neurology, Vienna, Austria, 3University of Zurich, Zurich, Switzerland, 4RehaClinic, Bad Zurzach & Baden, Switzerland, 5Swiss Federal Institute of Technology, Zurich, Switzerland, 6University of Birmingham, Birmingham, United Kingdom

Although it has been described that cerebral blood flow and cortical excitability is altered in migraineurs, it is unknown if these processes may be differentially involved in chronic and episodic forms of the disease. We used arterial spin labeling MRI und magnetic resonance spectroscopy (GABA-editing) to address this problem. We found lower levels of combined glutamate and glutamine in chronic and episodic migraineurs relative to controls. Chronic patients showed hypoperfusion relative to controls and episodic migraineurs. Our results might indicate severe signs of cortical spreading depression in chronic migraineurs. The MRS findings suggest a disturbed excitation-inhibition balance in migraineurs.

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