Abstract #1428

Disruptions of resting state functional MRI networks in comatose cardiac arrest patients

Ona Wu¹, Brian L. Edlow², Katherine Mott¹, Gaston Cudemus-Deseda³, Ming Ming Ning², Marjorie Villien¹, William A. Copen⁴, James L. Januzzi⁵, Joseph T. Giacino⁶, Eric S. Rosenthal², and David M. Greer⁷

¹Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁵Department of Cardiology, Massachusetts General Hospital, Boston, MA, United States, ⁶Department of Psychiatry, Spaulding Rehabilitation Hospital, Charlestown, MA, United States, ⁷Department of Neurology, Yale School of Medicine, New Haven, CT, United States

Cardiac arrest patients who were comatose for more than 24 hours were prospectively studied to determine whether changes in the default mode network (DMN) and thalamocortical network (TCN) can be used to predict recovery of arousal. Arousal recovery was defined as either spontaneous eye opening or eye opening in response to stimuli prior to discharge. All patients had significantly altered DMN and TCN networks compared to healthy controls, with patients who failed to demonstrate eye opening having significantly greater disruption. Resting-state functional MRI may play an important role in predicting recovery and patient management decisions in comatose cardiac arrest patients.

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