Abstract #1429

Can Resting-State fMRI Distinguish Healthy Tissues from Perfusion and Diffusion Lesions in Patients with Cerebrovascular Disease?

Thomas Christen¹, Samantha Holdsworth¹, Hesamoddin Jahanian¹, Michael Moseley¹, and Greg Zaharchuk¹

¹Radiology, Stanford University, Stanford, CA, United States

In this work, we acquired whole brain, high-temporal resolution resting-state BOLD fMRI in 10 healthy volunteers, 10 stroke patients, and 8 Moyamoya patients. Using information from co-registered perfusion and diffusion-weighted images, we defined 4 classes of tissue (healthy tissue, chronic perfusion deficit, acute diffusion core, and mismatch) and examined the spontaneous BOLD fluctuation patterns in these different regions. The results suggest that a single, short rs-fMRI sequence contains enough information to distinguish different tissue types in patients with cerebrovascular diseases, obviating the need for gadolinium and potentially dramatically shortening the duration of an acute stroke MR study.

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