Thomas Christen1, Samantha Holdsworth1, Hesamoddin Jahanian1, Michael Moseley1, and Greg Zaharchuk1
In this work, we acquired whole brain,
high-temporal resolution resting-state BOLD fMRI in 10 healthy volunteers, 10 stroke
patients, and 8 Moyamoya patients. Using information from co-registered perfusion
and diffusion-weighted images, we defined 4 classes of tissue (healthy tissue, chronic
perfusion deficit, acute diffusion core, and mismatch) and examined the
spontaneous BOLD fluctuation patterns in these different regions. The results
suggest that a single, short rs-fMRI sequence contains enough information to
distinguish different tissue types in patients with cerebrovascular diseases, obviating the need for gadolinium and potentially dramatically
shortening the duration of an acute stroke MR study.
