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Abstract #1430

Early extravasation of the experimental contrast agent GadoflurineM in ischemic stroke predicts infarct severity

Angelika Hoffmann1, Xavier Helluy1, Tassilo Dege1, Reiner Kunze2, Hugo Marti2, Sabine Heiland1, Martin Bendszus1, and Mirko Pham1

1Neuroradiology, University of Heidelberg, Heidelberg, Germany, 2Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany

Very early post ischemic blood-brain barrier disruption has been difficult to detect in vivo. In this study we show that the experimental contrast agent Gadofluorine M visualizes very early blood-brain barrier disruption in a mouse model of ischemic stroke at 9.4T. Contrast agent leakage occurs multifocally along cortical and subcortical microvessels. The degree of leakage predicts final infarct severity and could therefore serve as a new predictive marker in ischemic stroke.

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