Abstract #1430

Early extravasation of the experimental contrast agent GadoflurineM in ischemic stroke predicts infarct severity

Angelika Hoffmann¹, Xavier Helluy¹, Tassilo Dege¹, Reiner Kunze², Hugo Marti², Sabine Heiland¹, Martin Bendszus¹, and Mirko Pham¹

¹Neuroradiology, University of Heidelberg, Heidelberg, Germany, ²Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany

Very early post ischemic blood-brain barrier disruption has been difficult to detect in vivo. In this study we show that the experimental contrast agent Gadofluorine M visualizes very early blood-brain barrier disruption in a mouse model of ischemic stroke at 9.4T. Contrast agent leakage occurs multifocally along cortical and subcortical microvessels. The degree of leakage predicts final infarct severity and could therefore serve as a new predictive marker in ischemic stroke.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.