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Abstract #1432

Quantitative Perfusion, Oxygenation, and CMRO2 Imaging in Post-Acetazolamide Moyamoya Disease Patients

Wendy Ni1,2, Thomas Christen2, and Greg Zaharchuk2

1Department of Electrical Engineering, Stanford University, Stanford, CA, United States, 2Department of Radiology, Stanford University, Stanford, CA, United States

The acetazolamide challenge can be used to assess cerebrovascular reserve and oxygenation in patients with steno-occlusive diseases such Moyamoya, thus enabling evaluation of the quantitative blood oxygen-level dependent (qBOLD) approach of modeling tissue oxygenation. In this study, we mapped post-acetazolamide oxygenation (with transverse relaxation rate R2’), CBF with arterial spin labeling (ASL), and CBV with dynamic susceptibility contrast (DSC). We found that angiographically abnormal tissues are relatively hypoperfused and hypoxic. Finally, we investigated a qBOLD biophysical model for quantitative tissue oxygenation which suggested no difference in the cerebral metabolic rate of oxygen consumption (CMRO2) between normal and affected regions.

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