Abstract #1432

Quantitative Perfusion, Oxygenation, and CMRO2 Imaging in Post-Acetazolamide Moyamoya Disease Patients

Wendy Ni^1,2, Thomas Christen², and Greg Zaharchuk²

¹Department of Electrical Engineering, Stanford University, Stanford, CA, United States, ²Department of Radiology, Stanford University, Stanford, CA, United States

The acetazolamide challenge can be used to assess cerebrovascular reserve and oxygenation in patients with steno-occlusive diseases such Moyamoya, thus enabling evaluation of the quantitative blood oxygen-level dependent (qBOLD) approach of modeling tissue oxygenation. In this study, we mapped post-acetazolamide oxygenation (with transverse relaxation rate R₂’), CBF with arterial spin labeling (ASL), and CBV with dynamic susceptibility contrast (DSC). We found that angiographically abnormal tissues are relatively hypoperfused and hypoxic. Finally, we investigated a qBOLD biophysical model for quantitative tissue oxygenation which suggested no difference in the cerebral metabolic rate of oxygen consumption (CMRO₂) between normal and affected regions.

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