Abstract #1435

Analysis Methods for Breath-Hold Based Cerebrovascular Reactivity in an Intraoperative Setup

Marco Piccirelli¹, Christiaan Hendrik Bas van Niftrik², Oliver Bozinov², Athina Pangalu¹, Antonio Valavanis¹, Luca Regli², and Jorn Fierstra²

¹Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ²Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland

For the first time during neurosurgery, we determinate intraoperative CVR with Blood Oxygen-Level Dependent (BOLD) fMRI measurements with three cycles of apnea (mimicking BH) in mechanically ventilated neurosurgical patients.
BOLD fMRI datasets of five neurovascular patients with unilateral hemispheric hemodynamic impairment were processed with various BH CVR analysis methods. Temporal lag (Phase), percent BOLD signal change (CVR) and explained variance (Coherence) maps were calculated using three different Sine models and two novel “Optimal Signal” model-free methods.
Our analysis methods make the intraoperative determination of CVR possible, and increase sensitivity and reproducibility of BH derived BOLD fMRI CVR.

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