Abstract #1436

Co-existing Atherosclerotic Plaques in Intra- and Extra-cranial Arteries and Recurrent Stroke Risk: A 3D MR Vessel Wall Imaging Study

Yilan Xu¹, Zechen Zhou², Le He², Donghua Mi³, Rui Li², Chun Yuan^2,4, and Xihai Zhao²

¹Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, China, People's Republic of, ²Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, ³Department of Neurology, Beijing Tiantan Hospital, Beijing, China, People's Republic of, ⁴Department of Radiology, University of Washington, Seattle, WA, United States

This study investigated the characteristics of co-existing intra- and extra-cranial atherosclerotic plaques and their relationships with recurrent stroke by using 3D multicontrast vessel wall imaging techniques. We found that 77.6% of stroke patients had co-existing intra- and extra-cranial plaques. The number of co-existing plaques was significantly associated with recurrent stroke before (OR=2.42; 95% CI, 1.04-5.64; p=0.040) and after adjusted for traditional risk factors (OR=3.31; 95% CI, 1.09-10.08; p=0.035). Our findings suggest that the co-existing intra- and extra-cranial plaques are prevalent in stroke patients and the number of co-existing plaques might be an independent indicator for risk of recurrent stroke.

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