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Abstract #1436

Co-existing Atherosclerotic Plaques in Intra- and Extra-cranial Arteries and Recurrent Stroke Risk: A 3D MR Vessel Wall Imaging Study

Yilan Xu1, Zechen Zhou2, Le He2, Donghua Mi3, Rui Li2, Chun Yuan2,4, and Xihai Zhao2

1Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, China, People's Republic of, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, 3Department of Neurology, Beijing Tiantan Hospital, Beijing, China, People's Republic of, 4Department of Radiology, University of Washington, Seattle, WA, United States

This study investigated the characteristics of co-existing intra- and extra-cranial atherosclerotic plaques and their relationships with recurrent stroke by using 3D multicontrast vessel wall imaging techniques. We found that 77.6% of stroke patients had co-existing intra- and extra-cranial plaques. The number of co-existing plaques was significantly associated with recurrent stroke before (OR=2.42; 95% CI, 1.04-5.64; p=0.040) and after adjusted for traditional risk factors (OR=3.31; 95% CI, 1.09-10.08; p=0.035). Our findings suggest that the co-existing intra- and extra-cranial plaques are prevalent in stroke patients and the number of co-existing plaques might be an independent indicator for risk of recurrent stroke.

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