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Abstract #1439

Magnetic Resonance Imaging Detection of Multiple Ischemic Injury Produced by a Mild Transient Cerebral Ischemia Preceded by an Experimental Minor Stroke

Ursula I. Tuor1,2, Min Qiao1, David Rushforth2, and Tadeusz Foniok2

1Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada, 2Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada

A mild photothrombosis elicited an initial ischemic insult consisting of a small cortical infarct overlying a peri-infarct region of scattered necrosis. One, 2 or 7 days later a relatively short transient middle cerebral artery occlusion was produced. Peri-infarct regions were observed to be susceptible to the second (1 or 2 day later) ischemic event appearing as enhanced T2 increases and increased tissue damage. With one week between insults, there was no T2 increase and less ischemic damage in the peri-infarct region. The results are relevant for improving diagnosis and management of patients with recurrent transient ischemic insults.

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