Abstract #1439

Magnetic Resonance Imaging Detection of Multiple Ischemic Injury Produced by a Mild Transient Cerebral Ischemia Preceded by an Experimental Minor Stroke

Ursula I. Tuor^1,2, Min Qiao¹, David Rushforth², and Tadeusz Foniok²

¹Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada, ²Experimental Imaging Centre, University of Calgary, Calgary, AB, Canada

A mild photothrombosis elicited an initial ischemic insult consisting of a small cortical infarct overlying a peri-infarct region of scattered necrosis. One, 2 or 7 days later a relatively short transient middle cerebral artery occlusion was produced. Peri-infarct regions were observed to be susceptible to the second (1 or 2 day later) ischemic event appearing as enhanced T2 increases and increased tissue damage. With one week between insults, there was no T2 increase and less ischemic damage in the peri-infarct region. The results are relevant for improving diagnosis and management of patients with recurrent transient ischemic insults.

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