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Abstract #1438

Characterizing diffusion heterogeneity changes after acute ischemic stroke

Ona Wu1, Arne Lauer2, Gregoire Boulouis2, Lisa Cloonan2, Mark Etherton2, Abigail S. Cohen2, Pedro T. Cougo-Pinto2, Katherine Mott1, William A. Copen3, and Natalia S. Rost2

1Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, 3Department of Radiology, Massachusetts General Hospital, Boston, MA, United States

Diffusion kurtosis imaging (DKI) has been suggested to be a more sensitive marker for microstructural injury than diffusion tensor imaging (DTI). To investigate this hypothesis, we analyzed DKI data from acute ischemic stroke patients enrolled in a prospective serial MRI study (N=18). Axial diffusivity and axial kurtosis values within the ischemic core were significantly correlated with time-to-MRI. Regional differences in both diffusivity and kurtosis were observed as a function of tissue outcome suggesting DKI may provide complementary information to that obtained from DTI.

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