Abstract #1438

Characterizing diffusion heterogeneity changes after acute ischemic stroke

Ona Wu¹, Arne Lauer², Gregoire Boulouis², Lisa Cloonan², Mark Etherton², Abigail S. Cohen², Pedro T. Cougo-Pinto², Katherine Mott¹, William A. Copen³, and Natalia S. Rost²

¹Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Neurology, Massachusetts General Hospital, Boston, MA, United States, ³Department of Radiology, Massachusetts General Hospital, Boston, MA, United States

Diffusion kurtosis imaging (DKI) has been suggested to be a more sensitive marker for microstructural injury than diffusion tensor imaging (DTI). To investigate this hypothesis, we analyzed DKI data from acute ischemic stroke patients enrolled in a prospective serial MRI study (N=18). Axial diffusivity and axial kurtosis values within the ischemic core were significantly correlated with time-to-MRI. Regional differences in both diffusivity and kurtosis were observed as a function of tissue outcome suggesting DKI may provide complementary information to that obtained from DTI.

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