Abstract #1441

Dynamic Changes of Amide Proton Transfer (APT) and Multi-parametric MRI Signals in Transient Focal Ischemia in Rats

Dong-Hoon Lee¹, Xuna Zhao¹, Hye-Young Heo¹, Yi Zhang¹, Shanshan Jiang¹, and Jinyuan Zhou¹

¹Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

APT MRI is a novel imaging technique to provide in vivo image contrasts related with the changes of endogenous mobile amide proton concentration and/or tissue pH. In this abstract, based on the quantified APT signals and multi-parametric MR images, we attempted to evaluate signal changes in transient focal ischemia in rat models. Our results clearly showed that the APT imaging can be a useful technique to predict the ischemia reperfusion status, and to provide the quantitative results more accurately.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.