Abstract #1442

Quantitative in vivo MRI study of Dahl and Sprague-Dawley rat brains in response to salt loading

Kenneth W Fishbein¹, Mikayla L Hall¹, Mustapha Bouhrara¹, Yulia Grigorova¹, Jeffrey Long¹, Christopher A Morrell¹, Edward G Lakatta¹, Peter Rapp¹, Alexei Y Bagrov¹, Richard G Spencer¹, and Olga V Fedorova¹

¹National Institute on Aging, National Institutes of Health, Baltimore, MD, United States

Dahl salt-sensitive rats are a common preclinical model for hypertension. We compared brain morphology and MRI contrast parameters (T₂, T₂*, MTR and diffusion) in Dahl and Sprague-Dawley rats on low-salt and high-salt diets. Two of five Dahl rats on a high-salt diet exhibited stroke lesions on T₂ and diffusion-weighted images. Dahl rats had smaller brain and hippocampus volumes and larger percent ventricular volume relative to Sprague-Dawley rats, regardless of diet. Dahl rats on the high-salt diet had thinner cortex, and longer T₂ and shorter T₂* in whole brain (excluding lesions and ventricles). Dahl rat brains therefore exhibit distinct morphological and contrast features on MRI, some of which are independent of salt loading.

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