Abstract #1443

High resolution MRI and DTI in a Genetic Mouse Model of Neonatal Hypoxia-Ischemia Injury

Cynthia Yang¹, Daniele Procissi¹, and Maria L Dizon^2,3

¹Radiology, Northwestern University, Chicago, IL, United States, ²Pediatrics, Northwestern University, Chicago, IL, United States, ³Neonatology Division, Prentice Women's Hospital, Chicago, IL, United States

White matter injury in the neonatal brain is characterized by lifelong abnormalities in motor control and plasticity. In vivo assessment of experimental interventions are necessary for the development of novel preventive therapies which are currently lacking. We tested multi direction (64 directions) and multiple b-values (0, 900, 1800 sec/mm²) DTI as a means to monitor changes and progression of neurological disorders and reorganization following HI injury in a mouse model overexpressing microRNA-21.

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