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Abstract #1443

High resolution MRI and DTI in a Genetic Mouse Model of Neonatal Hypoxia-Ischemia Injury

Cynthia Yang1, Daniele Procissi1, and Maria L Dizon2,3

1Radiology, Northwestern University, Chicago, IL, United States, 2Pediatrics, Northwestern University, Chicago, IL, United States, 3Neonatology Division, Prentice Women's Hospital, Chicago, IL, United States

White matter injury in the neonatal brain is characterized by lifelong abnormalities in motor control and plasticity. In vivo assessment of experimental interventions are necessary for the development of novel preventive therapies which are currently lacking. We tested multi direction (64 directions) and multiple b-values (0, 900, 1800 sec/mm2) DTI as a means to monitor changes and progression of neurological disorders and reorganization following HI injury in a mouse model overexpressing microRNA-21.

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