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Abstract #1445

Diffusion and Multi-delay Arterial Spin Labeling Imaging of Cerebral Blood Flow, Cerebrovascular Reserve, and Transit Time in Moyamoya Disease Before and After Acetazolamide Challenge

Christian Federau1, Soren Christensen1, Zungho Zun2, Sun-Won Park3, Wendy Ni1, Michael Moseley1, and Greg Zaharchuk1

1Stanford University, Stanford, CA, United States, 2Children's National Medical Center, Washington, DC, United States, 3Seoul National University, Seoul, Korea, Republic of

We assessed the changes in arterial spin labeling cerebral blood flow (CBF) and arterial transit time (ATT), as well as in apparent diffusion coefficient (ADC), before and after acetazolamide challenge in preoperative Moyamoya patients as function of the severity of feeding vessel stenosis. We found a significant increase after acetazolamide challenge in CBF (mL/min/100g) in territories of normal (50.9±19.0 to 66.8±19.3, p<0.0001) and mildly stenosed (52.9±18.8 to 66.2±23.4, p < 0.0001) vessels, but not in severely stenosed/occluded vessels (57.8±31.7 to 58.1±23.4, NS). ATT significantly decreased but no change in ADC was identified after acetazolamide.

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