Abstract #1445

Diffusion and Multi-delay Arterial Spin Labeling Imaging of Cerebral Blood Flow, Cerebrovascular Reserve, and Transit Time in Moyamoya Disease Before and After Acetazolamide Challenge

Christian Federau¹, Soren Christensen¹, Zungho Zun², Sun-Won Park³, Wendy Ni¹, Michael Moseley¹, and Greg Zaharchuk¹

¹Stanford University, Stanford, CA, United States, ²Children's National Medical Center, Washington, DC, United States, ³Seoul National University, Seoul, Korea, Republic of

We assessed the changes in arterial spin labeling cerebral blood flow (CBF) and arterial transit time (ATT), as well as in apparent diffusion coefficient (ADC), before and after acetazolamide challenge in preoperative Moyamoya patients as function of the severity of feeding vessel stenosis. We found a significant increase after acetazolamide challenge in CBF (mL/min/100g) in territories of normal (50.9±19.0 to 66.8±19.3, p<0.0001) and mildly stenosed (52.9±18.8 to 66.2±23.4, p < 0.0001) vessels, but not in severely stenosed/occluded vessels (57.8±31.7 to 58.1±23.4, NS). ATT significantly decreased but no change in ADC was identified after acetazolamide.

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