Abstract #1446

High lesion-to-wall contrast ratio in intracranial arterial wall imaging using whole-brain IR-SPACE: A potential approach to stroke etiology assessment without the need for MR contrast media

Zhaoyang Fan¹, Qi Yang^1,2, Shlee Song³, Xiuhai Guo⁴, Wouter Schievink⁵, Xiaoming Bi⁶, Gerhard Laub⁶, Patrick Lyden³, and Debiao Li^1,7

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Radiology, Xuanwu Hospital, Beijing, China, People's Republic of, ³Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁴Neurology, Xuanwu Hospital, Beijing, China, People's Republic of, ⁵Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ⁶MR R&D, Siemens Healthcare, Los Angeles, CA, United States, ⁷Bioengineering, University of California, Los Angeles, CA, United States

Variable-flip-angle 3D fast spin-echo (SPACE) has emerged as a promising imaging technique to assess intracranial wall abnormalities. Gadolinium-based MR contrast medium is usually used to highlight wall lesions which are sometimes unclear on pre-contrast vessel wall images in part due to suboptimal lesion-to-wall contrast. A whole-brain inversion-recovery-prepared SPACE sequence has recently been developed to improve vessel wall delineation by substantially enhanced T1 contrast weighting and cerebrospinal fluid attenuation. To test the hypothesis that the sequence may be used for noncontrast wall evaluation, we evaluated the lesion-to-wall contrast on pre-contrast images from a group of stroke and transient ischemic attack patients.

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