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Abstract #1447

Whole-Brain CBF and BAT Template Measured by Multi-TI Arterial Spin-Labeling Technique and Its Application in Cerebellar Infarction

Yelong Shen1, Bin Zhao1, Guangbin Wang1, Shuang Yang1, Shan Li2, Josef Pfeuffer3, and Tianyi Qian4

1Shandong Medical Imaging Research Institute, School of Medicine, Jinan, China, People's Republic of, 2Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, China, People's Republic of, 3Siemens Healthcare, Application Development, Erlangen, Germany, Erlangen, Germany, 4Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of

Single-TI ASL usually underestimates the cerebral blood flow in areas with longer blood arrival time, especially in the cerebellum. In this study, we built a template of whole-brain cerebral blood flow and blood arrival time based on multi-inversion time-ASL (mTI-ASL). No significant differences were found when comparing young vs. old groups and female vs. male groups. The application in cerebellar infarction patients demonstrates that mTI-ASL performs better than sTI-ASL especially in areas with longer BAT. The CBF/BAT template created based on normal subjects could be used to better identify perfusion deficits.

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