Abstract #1447

Whole-Brain CBF and BAT Template Measured by Multi-TI Arterial Spin-Labeling Technique and Its Application in Cerebellar Infarction

Yelong Shen¹, Bin Zhao¹, Guangbin Wang¹, Shuang Yang¹, Shan Li², Josef Pfeuffer³, and Tianyi Qian⁴

¹Shandong Medical Imaging Research Institute, School of Medicine, Jinan, China, People's Republic of, ²Department of Neurology, Provincial Hospital Affiliated to Shandong University, Jinan, China, People's Republic of, ³Siemens Healthcare, Application Development, Erlangen, Germany, Erlangen, Germany, ⁴Siemens Healthcare, MR Collaborations NE Asia, Beijing, China, People's Republic of

Single-TI ASL usually underestimates the cerebral blood flow in areas with longer blood arrival time, especially in the cerebellum. In this study, we built a template of whole-brain cerebral blood flow and blood arrival time based on multi-inversion time-ASL (mTI-ASL). No significant differences were found when comparing young vs. old groups and female vs. male groups. The application in cerebellar infarction patients demonstrates that mTI-ASL performs better than sTI-ASL especially in areas with longer BAT. The CBF/BAT template created based on normal subjects could be used to better identify perfusion deficits.

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