Abstract #1469

Detection of neuronal activities concerning the retrieval of the conditioned taste aversion with lipopolysaccharide

Chizuko Inui-Yamamoto¹, Fuminori Sugihara¹, Yuki Mori¹, Ting Chen¹, Zhenyu Cheng¹, Yutaka Komai², and Yoshichika Yoshioka¹

¹Biofunctional Imaging, WPI IFReC, Osaka University, Suita, Japan, ²Single Molecule Imaging, WPI IFReC, Osaka University, Suita, Japan

It is well known lipopolysaccharides (LPS) is produced by infected bacteria and triggers several acute phase responses after infection. Some reports show that rodents can acquire aversion to the taste stimulus paired with LPS. However, the brain mechanisms in the conditioned taste aversion (CTA) with LPS and in its retrieval remain obscure. To elucidate the brain mechanism in the retrieval of CTA with LPS (LPS-CTA), we tried to visualize the brain activities by using the manganese enhanced MRI (MEMRI). In consequence, we found the activation of DMH in relation with the regulation of body temperature in the retrieval of LPS-CTA cause body.

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