Abstract #1470

3D CMRO2 mapping in human brain with direct 17O-MRI and proton-constrained iterative reconstructions

Dmitry Kurzhunov¹, Robert Borowiak^1,2, Marco Reisert¹, Philipp Wagner¹, Axel Krafft^1,2, and Michael Bock¹

¹University Medical Center Freiburg, Dept. of Radiology - Medical Physics, Freiburg, Germany, ²German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany

This work presents a comparison analysis of different reconstruction techniques for quantification of 3D maps of the cerebral metabolic rate of oxygen consumption (CMRO₂) in human brain. Several ¹⁷O-MR 3D data sets of a healthy volunteer’s brain were acquired at a clinical 3 Tesla MR system with inhalation of 70%-enriched ¹⁷O₂ gas. Iterative image reconstruction procedures, e.g. where different co-registered ¹H MR image data sets of high spatial resolution act as edge-preserving constraints, are compared and used to improve the image quality and the precision of CMRO₂ mapping. Anisotropic Diffusion as non-Homogeneous Constraint (ADHOC) is shown to be superior.

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