Abstract #1473

Tissue Partial Volume Correction of Perfusion Maps in Dynamic Susceptibility Contrast MRI

André Ahlgren¹, Ronnie Wirestam¹, Freddy Ståhlberg^1,2,3, and Linda Knutsson¹

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden, ²Department of Diagnostic Radiology, Lund University, Lund, Sweden, ³Lund University Bioimaging Center, Lund University, Lund, Sweden

Partial volume effects (PVE) can significantly affect parameter estimates in perfusion MRI. In contrast to arterial spin labeling (ASL), the impact of PVEs in dynamic susceptibility contrast MRI (DSC-MRI) has not yet been well established. In this work, we assess and compare partial volume correction (PVC) of DSC-MRI and ASL data in 20 healthy subjects. PVC reduced the tissue volume dependence of perfusion estimates in DSC-MRI and ASL. White matter perfusion maps were of higher quality for DSC-MRI. However, for PVC of DSC-MRI we used several assumptions which need further evaluation.

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