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Abstract #1474

Improved Vascular Transport Function Characterization in DSC-MRI via Deconvolution with Dispersion-Compliant Bases

Marco Pizzolato1, Rutger Fick1, Timothé Boutelier2, and Rachid Deriche1

1Athena Project-Team, Inria Sophia Antipolis - Méditerranée, Sophia Antipolis, France, 2Olea Medical, La Ciotat, France

Bolus dispersion phenomena affect the residue function computed via deconvolution of DSC-MRI data. Indeed the obtained effective residue function can be expressed as the convolution of the true one with a Vascular Transport Function (VTF) that characterizes the dispersion. The state-of-the-art technique CPI+VTF allows to estimate the actual residue function by assuming a model for the VTF. We propose to perform deconvolution representing the effective residue function with Dispersion-Compliant Bases (DCB) without assumptions on the VTF, and then apply the CPI+VTF on DCB results. We show that DCB improve robustness to noise and allow to better characterize the VTF.

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