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Abstract #1479

Dynamic contrast-enhanced MRI in primary rectal cancer: correlation with histologic prognostic factors

Zhe Han1,2, Juan Chen2, Min Chen2, Chen Zhang2, and Dandan Zheng3

1Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, People's Republic of, 2Department of Radiology, Beijing Hospital, Beijing, China, People's Republic of, 3GE Healthcare, MR Research China, Beijing, China, People's Republic of

In this study we compared the association of dynamic contrast-enhanced (DCE)-derived quantitative parameters with the histologic grade, N-stage, epidermal growth factor receptor (EGFR) expression and K-RAS gene mutation of primary rectal cancer.Significant correlations were found between Ktrans values and N-stage, Ktrans values and EGFR expression, Kep values and EGFR expression. DCE-derived quantitative parameters may be a promising imaging biomarker of tumor aggressiveness and prognosis.

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