Abstract #1479

Dynamic contrast-enhanced MRI in primary rectal cancer: correlation with histologic prognostic factors

Zhe Han^1,2, Juan Chen², Min Chen², Chen Zhang², and Dandan Zheng³

¹Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, People's Republic of, ²Department of Radiology, Beijing Hospital, Beijing, China, People's Republic of, ³GE Healthcare, MR Research China, Beijing, China, People's Republic of

In this study we compared the association of dynamic contrast-enhanced (DCE)-derived quantitative parameters with the histologic grade, N-stage, epidermal growth factor receptor (EGFR) expression and K-RAS gene mutation of primary rectal cancer.Significant correlations were found between Ktrans values and N-stage, Ktrans values and EGFR expression, Kep values and EGFR expression. DCE-derived quantitative parameters may be a promising imaging biomarker of tumor aggressiveness and prognosis.

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