Abstract #1486

Whole brain volumetric perfusion imaging with high spatial resolution using simultaneous multi-slab (SMSB) 3D GRASE pCASL

Yi Wang¹, Xingfeng Shao¹, Steen Moeller², and Danny JJ Wang¹

¹Neurology, UCLA, Los Angeles, CA, United States, ²Center of Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States

The temporal SNR of simultaneous multi-slice (SMS) 2D EPI ASL has been shown to be inferior to that of 3D background suppressed GRASE. In this work, we present a novel simultaneous multi-slab (SMSB) 3D GRASE sequence for volumetric pCASL imaging with high spatial resolution. The image quality of SMSB-GRASE was evaluated and compared to a standard 3D GRASE pCASL sequence. Preliminary results demonstrated the feasibility for whole-brain volumetric perfusion imaging at a high spatial resolution, although the drop in RF slice profiles in the overlapped boundary slices still needs to be addressed in future work.

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