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Abstract #1490

Priors-guided adaptive outlier cleaning for arterial spin labeling perfusion MRI

Ze Wang1,2

1Hangzhou Normal University, Hangzhou, China, People's Republic of, 2Psychiatry and Radiology, University of Pennsylvania, PHILADELPHIA, PA, United States

ASL CBF signal is derived from the difference between successive labeling and no-labeling images. The low signal-to-noise-ratio and the pairwise subtraction can then result in outliers, which can significantly degrade CBF quantification quality in a typical several minutes scan. A priors-guided adaptive outlier cleaning algorithm was verified in this study. Our results showed that the proposed method improved both CBF quantification quality and CBF measurement stability.

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