Abstract #1490

Priors-guided adaptive outlier cleaning for arterial spin labeling perfusion MRI

Ze Wang^1,2

¹Hangzhou Normal University, Hangzhou, China, People's Republic of, ²Psychiatry and Radiology, University of Pennsylvania, PHILADELPHIA, PA, United States

ASL CBF signal is derived from the difference between successive labeling and no-labeling images. The low signal-to-noise-ratio and the pairwise subtraction can then result in outliers, which can significantly degrade CBF quantification quality in a typical several minutes scan. A priors-guided adaptive outlier cleaning algorithm was verified in this study. Our results showed that the proposed method improved both CBF quantification quality and CBF measurement stability.

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