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Abstract #1491

Improving SNR in pulsed arterial spin labeling using multiple inversion modules (MM-PASL)

Jia Guo1, Richard B. Buxton1, and Eric C. Wong1,2

1Radiology, UC San Diego, La Jolla, CA, United States, 2Psychiatry, UC San Diego, La Jolla, CA, United States

The bolus duration in pulsed arterial spin labeling (PASL) is typically short, resulting in low SNR. We propose using multiple inversion pulses to increase the total bolus duration for improved SNR. In this study, a wedge-shaped inversion was combined with a regular slab inversion and a QUIPSS II pulse to lengthen the total bolus duration while keeping the ASL signal quantitative. The preliminary in vivo results showed an SNR improvement of 54% in gray matter, in good agreement with theory, compared to a regular PASL scan. The mean GM CBF values were consistent with PCASL reference scans. This new labeling method should benefit studies using PASL.

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