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Abstract #1493

Considerations of cardiac phase can improve ASL quality in multiple settings

Yang Li1,2, Deng Mao1,2, Zhiqiang Li3, Michael Schär1, James G. Pipe3, and Hanzhang Lu1

1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States, 3Imaging Research, Barrow Neurological Institute, Phoenix, AZ, United States

Recent studies have identified a cardiac-pulsation induced signal modulation in recommended ASL implementation (pseudocontinuous labeling 1.8s/post-labeling delay 1.8s/background-suppression/3D acquisition). In pCASL with single-shot readout, the ASL signal fluctuation could be reduced by cardiac-triggering scheme. Here is this study, we aim to extend the scope and provide possible solutions to other pCASL settings that suffer from pulsation effect, such as pCASL with 3D segmented readout, perfusion change detecting in CBF manipulations (e.g. hypercapnia), and regular pCASL when cardiac-triggering sequence is not available. We have demonstrated that considerations of cardiac phase can improve ASL data quality in multiple settings.

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