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Abstract #1496

Deformation and resolution issues in partial volume correction of 2D arterial spin labeling data

Jan Petr1, Henri JMM Mutsaerts2, Enrico De Vita3,4, Jens Maus1, Jörg van den Hoff1, and Iris Asllani5

1Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, 4Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, 5Department of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States

Partial volume (PV) effects are a well-recognized confounder in arterial spin labeling due to its limited spatial resolution. Several algorithms exist to correct for these errors. Nevertheless, PV-correction is rarely used, mainly because the PV maps obtained from segmented T1-weighted images are regarded as not being sufficiently reliable when transformed into ASL space. Here, we show the impact of spatial deformation and resolution in the PV-maps used for PV-correction in the calculation of mean total gray matter (GM) cerebral blood flow (CBF). We also show how the deformations affect the calculation of PV-uncorrected mean GM CBF.

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