Abstract #1496

Deformation and resolution issues in partial volume correction of 2D arterial spin labeling data

Jan Petr¹, Henri JMM Mutsaerts², Enrico De Vita^3,4, Jens Maus¹, Jörg van den Hoff¹, and Iris Asllani⁵

¹Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ²Sunnybrook Research Institute, Toronto, ON, Canada, ³Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, London, United Kingdom, ⁴Academic Neuroradiological Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom, ⁵Department of Biomedical Engineering, Rochester Institute of Technology, Rochester, NY, United States

Partial volume (PV) effects are a well-recognized confounder in arterial spin labeling due to its limited spatial resolution. Several algorithms exist to correct for these errors. Nevertheless, PV-correction is rarely used, mainly because the PV maps obtained from segmented T1-weighted images are regarded as not being sufficiently reliable when transformed into ASL space. Here, we show the impact of spatial deformation and resolution in the PV-maps used for PV-correction in the calculation of mean total gray matter (GM) cerebral blood flow (CBF). We also show how the deformations affect the calculation of PV-uncorrected mean GM CBF.

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