Abstract #1497

Multiphase pCASL for imaging blood flow in rodent brains

James R Larkin¹, Manon A Simard¹, Alexandre A Khrapitchev¹, Kevin J Ray¹, James A Meakin², Paul Kinchesh¹, Sean Smart¹, Peter Jezzard², Michael A Chappell³, and Nicola R Sibson¹

¹CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, ²FMRIB Centre, University of Oxford, Oxford, United Kingdom, ³Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Arterial spin labelling perfusion imaging in the rodent brain is easily confounded by off-resonance effects at the tagging plane. These effects are a consequence of the higher field strengths used pre-clinically and the nearby air cavities in the rodent head and neck, something not as problematic in the clinic. By implementing a multiphase pCASL sequence with eight phases spaced at 45° and lying between 0 and 315°, it is possible to obtain data to allow fitting thereby accounting for any off-resonance effects. This process dramatically improves image quality without excessively affecting acquisition time.

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