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Abstract #1497

Multiphase pCASL for imaging blood flow in rodent brains

James R Larkin1, Manon A Simard1, Alexandre A Khrapitchev1, Kevin J Ray1, James A Meakin2, Paul Kinchesh1, Sean Smart1, Peter Jezzard2, Michael A Chappell3, and Nicola R Sibson1

1CRUK and MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom, 2FMRIB Centre, University of Oxford, Oxford, United Kingdom, 3Institute of Biomedical Engineering, Department of Engineering, University of Oxford, Oxford, United Kingdom

Arterial spin labelling perfusion imaging in the rodent brain is easily confounded by off-resonance effects at the tagging plane. These effects are a consequence of the higher field strengths used pre-clinically and the nearby air cavities in the rodent head and neck, something not as problematic in the clinic. By implementing a multiphase pCASL sequence with eight phases spaced at 45° and lying between 0 and 315°, it is possible to obtain data to allow fitting thereby accounting for any off-resonance effects. This process dramatically improves image quality without excessively affecting acquisition time.

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