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Abstract #1498

Does cardiac triggering improve pCASL signal stability? Isolation of the effect of the last labeled spins by end-of-labeling triggering and extremely long labeling durations

Jasper Verbree1 and Matthias J.P. van Osch1

1Radiology Department; Leiden Institute for Brain and Cognition; C.J. Gorter Center for High-field MRI, Leiden University Medical Center, Leiden, Netherlands

In pCASL, the blood tagged at the end-of-labeling period is expected to contribute most to the perfusion signal due to T1 recovery of the labeled spins. The influence on PCASL of cardiac triggering at the end-of-labeling was assessed with simulations and subsequently applied in volunteers. Simulations predict a 9% variation in ASL-signal over the cardiac cycle. In-vivo measurements were unable to show the predicted effect nor a difference in tSNR. Combining with earlier findings concerning cardiac triggering, neither triggering start- or end of labeling triggering improves signal stability, suggesting that cardiac triggering is not beneficial for pCASL.

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