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Abstract #1499

Neurophysiological effects and dose response curve of tDCS stimulation assessed by pseudo-continuous Arterial Spin Labeling

Mayank V Jog1, Kay Jann2, Lirong Yan2, and Danny JJ Wang2

1Biomedical Engineering, University of California Los Angeles, Los Angeles, CA, United States, 2Neurology, University of California Los Angeles, Los Angeles, CA, United States

Transcranial Direct Current Stimulation (tDCS) is one of such neuromodulation techniques that applies a small current (1-2mA) using scalp electrodes. Though tDCS has been shown to improve cognition as well as clinical symptoms, the mechanism of action is still unclear.

In this study, we sought to evaluate the neurophysiological effects of tDCS in a typical bilateral motor montage through concurrent Cerebral Blood Flow (CBF) measurements using arterial spin labeling (ASL). We were able to reliably detect increased blood flow under the anode as well as CBF changes in brain-wide networks.

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