Abstract #1506

3D Clinical APTw MRI with Improved Contrast Homogeneity

Jochen Keupp¹, Jinyuan Zhou², and Osamu Togao³

¹Philips Research, Hamburg, Germany, ²Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Clinical Radiology, Kyushu University Hospital, Fukuoka, Japan

APTw MRI is an emerging technique for sensitive tissue characterization, in particular in oncology (e.g. tumor grading). Fast-spin-echo(FSE)-Dixon acquisition techniques allow efficient and simultaneous acquisition of APT weighted (APTw) and ΔB₀ information. An improved FSE-Dixon APTw acquisition protocol with intrinsic ΔB₀ correction was implemented on a clinical MRI scanner, using multiple averages with saturation at the amide chemical shift (Δω=+3.5ppm). Contrast homogeneity was evaluated in a volunteer study and is presented together with initial clinical results on brain tumor patients.

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