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Abstract #1507

In vivo application of lactate chemical exchange saturation transfer imaging: human exercise study

Catherine DeBrosse1, Ravi Nanga1, Puneet Bagga1, Mohammad Haris2, Hari Hariharan1, and Ravinder Reddy1

1Center for Magnetic Resonance and Optical Imaging, University of Pennsylvania, Philadelphia, PA, United States, 2Research Branch, Sidra Medical and Research Center, Doha, Qatar

Metabolic regulation is disrupted in many diseases. As a result, the levels of lactate present in the body are often affected and implicated in disease progression and clinical outcome. To better understand lactate metabolism, an imaging technique with high sensitivity and spatial resolution is required. In this study, a chemical exchange saturation transfer (CEST) magnetic resonance imaging method, based on the exchange between lactate hydroxyl proton and bulk water protons was used to image lactate. As proof-of-principle, LATEST was implemented in vivo in exercising human skeletal muscle to image the increased lactate that results from intense exercise.

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