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Abstract #1508

Amide Proton Transfer (APT) imaging of brain tumors at 7T: the role of tissue water T1-relaxation properties

Vitaliy Khlebnikov1, Daniel Polders2, Jeroen Hendrikse1, Pierre A Robe1, Eduard H Voormolen1, Peter R Luijten1, Dennis WJ Klomp1, and Hans Hoogduin1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Philips Healthcare, Best, Netherlands

The purpose of this study was to provide insight into the effect of water-T1-relaxation (T1w) on Amide Proton Transfer (APT) contrast in tumors. To this end, three different metrics of APT contrast, (mainly novel magnetization transfer ratio (MTRRex), relaxation-compensated MTRRex (AREX) and traditional asymmetry (MTRasym)) were compared in normal and tumor tissues in a variety of intracranial tumors at 7T. The strong correlation of MTRRex and MTRasym with T1w and the absence thereof in AREX suggests that much of APT contrast in tumors at 7T originates from the inherent tissue water-T1-relaxation properties.

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