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Abstract #1511

Quantitative analysis of the evolution of Multiple Sclerosis (MS) lesion MT and NOE pool concentrations using CEST analysis via MR fingerprinting

Nicolas Geades1, Amal Samaraweera2, William Morley1, Matthew Cronin3, Nikos Evangelou2, Penny Gowland1, and Olivier Mougin1

1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Division of Clinical Neuroscience, Queen’s Medical Centre, University of Nottingham, Nottingham, United Kingdom, 3Brain Imaging and Analysis Centre, Duke University, Durham, NC, United States

This study presents a method of acquiring quantitative MT and NOE concentration percentages of MS lesions over a period of 30 weeks. MT and NOE mean percentages were compared for WM lesion ROIs and NAWM ROIs, showing a clear drop of both MT and NOE when a lesion appears, followed by a gradual increase in concentrations in the following weeks, indicating remyelination. The fitting results are backed by a parallel repeatability study which shows the repeatability of the method and its noise levels. The results indicate that NOE fitting is very robust against variations in B1 compared to fitting MT.

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