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Abstract #1510

A Study on CrCEST Mapping in Human Brain at 7T MRI

Anup Singh1,2, Mohammad Haris3, Kejia Cai4, Hari Hariharan5, and Ravinder Reddy5

1Centre for Biomedical Enineering, Indian Institute of Technology Delhi, New Delhi, India, 2Biomedical Engineering, AIIMS Delhi, New Delhi, India, 3Research Branch, Sidra Medical and Research Center, Doha, Qatar, 4Department of Radiology, University of Illinois at Chicago, Chicago, IL, United States, 5Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Creatine(Cr) is a significant brain metabolite and its alterations has been reported in various disease conditions. In this study, chemical-exchange-saturation-transfer (CEST) MRI of Creatine(CrCEST) was performed in human brain at 7T MRI scanner. Numerical simulations were also carried out for evaluating contributions from other brain metabolites to CrCEST and a method to reduce this contamination was proposed based upon simulated data observations. Using, conventional CESTasy method, CrCEST has ~50% contribution from Cr. Using proposed subtraction based approach it is feasible to reduce contaminations from other metabolites/molecules and hence making CrCEST more specific to Cr.

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