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Abstract #1514

Chemical exchange-sensitive spin-lock MRI of glucose and deoxyglucose in brain tumors

Tao Jin1, Bistra Iordanova1, Ping Wang1, and Seong-Gi Kim2,3

1University of Pittsburgh, Pittsburgh, PA, United States, 22Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University, Kuwon, Korea, Republic of

Glucose uptake and metabolism are important biomarkers for tumor diagnosis and prognosis. Recent studies showed that the glucose uptake and metabolism can be measured by a chemical exchange sensitive spin-lock (CESL) MRI approach with administration of non-labelled glucose or analogs (glucoCESL), providing unique advantage over the widely used position emission tomography technique. In this preliminary study, we evaluated the efficacy of glucoCESL for the study of brain tumor. The sensitivity and spatiotemporal characteristics of CESL signal with administration of D-Glucose, 2-deoxy-D-glucose and L-glucose were compared.

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