Abstract #1514

Chemical exchange-sensitive spin-lock MRI of glucose and deoxyglucose in brain tumors

Tao Jin¹, Bistra Iordanova¹, Ping Wang¹, and Seong-Gi Kim^2,3

¹University of Pittsburgh, Pittsburgh, PA, United States, ²2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of, ³Department of Biomedical Engineering, Sungkyunkwan University, Kuwon, Korea, Republic of

Glucose uptake and metabolism are important biomarkers for tumor diagnosis and prognosis. Recent studies showed that the glucose uptake and metabolism can be measured by a chemical exchange sensitive spin-lock (CESL) MRI approach with administration of non-labelled glucose or analogs (glucoCESL), providing unique advantage over the widely used position emission tomography technique. In this preliminary study, we evaluated the efficacy of glucoCESL for the study of brain tumor. The sensitivity and spatiotemporal characteristics of CESL signal with administration of D-Glucose, 2-deoxy-D-glucose and L-glucose were compared.

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