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Abstract #1515

On Resonance VDMP Technique for Improved glucoCEST Detection in Brain Tumors

Xiang Xu1,2, Kannie WY Chan1,2, Huanling Liu1,3, Yuguo Li1,2, Guanshu Liu1,2, Peter C.M. van Zijl1,2, and Jiadi Xu1,2

1Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, 2F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, 3Department of Ultrasound, Guangzhou Panyu Central Hospital, Guangzhou, China, People's Republic of

An on-resonance variable delay multi-pulse (onVDMP) CEST technique was developed for the detection of fast-exchanging protons. The new method was applied to the detection of glucoCEST signal changes upon venous glucose injection in a mouse tumor model and compared with conventional cw-CEST method. Both methods highlight the tumor and the blood vessels upon glucose injection in mice brain implanted with brain tumors. However compared with cw-CEST, the onVDMP technique increased the tumor contrast to noise ratio by about 50% due to its sensitivity to total fast exchanging protons.

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