Abstract #1515

On Resonance VDMP Technique for Improved glucoCEST Detection in Brain Tumors

Xiang Xu^1,2, Kannie WY Chan^1,2, Huanling Liu^1,3, Yuguo Li^1,2, Guanshu Liu^1,2, Peter C.M. van Zijl^1,2, and Jiadi Xu^1,2

¹Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, United States, ²F.M. Kirby Research Center, Kennedy Krieger Institute, Baltimore, MD, United States, ³Department of Ultrasound, Guangzhou Panyu Central Hospital, Guangzhou, China, People's Republic of

An on-resonance variable delay multi-pulse (onVDMP) CEST technique was developed for the detection of fast-exchanging protons. The new method was applied to the detection of glucoCEST signal changes upon venous glucose injection in a mouse tumor model and compared with conventional cw-CEST method. Both methods highlight the tumor and the blood vessels upon glucose injection in mice brain implanted with brain tumors. However compared with cw-CEST, the onVDMP technique increased the tumor contrast to noise ratio by about 50% due to its sensitivity to total fast exchanging protons.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.