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Abstract #1516

Model-based Extraction of z-spectrum Asymmetry using SYmmetric basis (EASY)

Hoonjae Lee1,2 and Jaeseok Park3

1Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, 2Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, Republic of, 3Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

CEST MRI is an indirect molecular imaging technique, in which a small molecular signal is amplified by chemical exchange phenomenon. Multiple acquisition of imaging data with varying saturation frequencies, called z-spectrum acquisition, is typically performed, and then subtraction-based MTR asymmetry analysis is employed to investigate the effect of CEST on MRI. However, since the z-spectrum is additionally convoluted by inherent asymmetric MT, NOE, etc, conventional asymmetry analysis is prone to substantial errors. To tackle these problems, in this work we introduce a new, model-based extraction method of the z-spectrum asymmetry using symmetric basis (EASY) to directly characterize the signal sources of the asymmetric z-spectrum.

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