Abstract #1525

Model-based direct Extraction of z-spectrum Asymmetry from undersampled k-space using SYmmetric Basis (k-EASY)

Hoonjae Lee^1,2 and Jaeseok Park³

¹Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, ²Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea, Republic of, ³Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of

In chemical exchange saturation transfer (CEST) MRI, multiple acquisition of imaging data with varying saturation frequencies is typically performed, which prohibitively prolongs imaging time. Furthermore, conventional, subtraction-based MTR asymmetry analysis is prone to substantial errors, because the z-spectrum is convoluted by CEST as well as inherent asymmetric MT, nuclear Overhauser enhancement (NOE), etc. To tackle these problems, in this work we propose a new, model-based direct Extraction of the z-spectrum Asymmetry from undersampled k-space using SYmmetric basis (k-EASY) that incorporates main field inhomogeneity correction and z-spectrum asymmetry analysis into a framework of compressed sensing.

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