Abstract #1526

A CEST signal quantification method for non-steady state

Yi Wang¹, Bing Wu², Yang Fan², and Jia-Hong Gao¹

¹School of Physics, Peking University, Beijing, China, People's Republic of, ²MR Research group, GE Healthcare China, Beijing, China, People's Republic of

For quantitative analysis of CEST signal, it is crucial to decrease or eliminate the influence of parameters unrelated to chemical exchange thus emphasizing chemical exchange weight. Recently inverse Z-spectrum method realized analytical calibration but only in situation of steady state. We propose a novel analytical calibration method suitible to non-steady state situation, calculating new indexes which reflect chemical exchange weight better than those commonly used, and verifying its performance in phantom and in vivo experiment.This calibration method will be greatly helpful in quantitative CEST data analysis.

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