Abstract #1527

T2 of cerebrospinal fluid depends on glucose concentration

Alexia Daoust¹, Stephen Dodd¹, Govind Nair¹, Steven Jacobson¹, Daniel Reich¹, and Alan Koretsky¹

¹NINDS, NIH, Bethesda, MD, United States

There continues to be interest in using changes in CSF properties to image neurodegenerative diseases. To optimize MRI sequences that enable segmentation of CSF from tissue, we characterized the CSF relaxometric properties at various field strengths in vivo and in vitro. Our in vitro results suggest that in vivo T₂ value at high field is incorrect due to residual gradients and that low field is more optimal to quantify CSF relaxivity in vivo. We have shown an important difference of in vitro CSF T₂ vs saline T₂ that is mostly explained by the relaxivity of glucose.

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