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Abstract #1527

T2 of cerebrospinal fluid depends on glucose concentration

Alexia Daoust1, Stephen Dodd1, Govind Nair1, Steven Jacobson1, Daniel Reich1, and Alan Koretsky1

1NINDS, NIH, Bethesda, MD, United States

There continues to be interest in using changes in CSF properties to image neurodegenerative diseases. To optimize MRI sequences that enable segmentation of CSF from tissue, we characterized the CSF relaxometric properties at various field strengths in vivo and in vitro. Our in vitro results suggest that in vivo T2 value at high field is incorrect due to residual gradients and that low field is more optimal to quantify CSF relaxivity in vivo. We have shown an important difference of in vitro CSF T2 vs saline T2 that is mostly explained by the relaxivity of glucose.

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