Abstract #1528

Temperature dependence of R1, R2* and magnetic susceptibility of ferritin at 7T

Mobeen Ali¹, Penny Gowland¹, and Richard Bowtell¹

¹SPMIC, School of Physics and Astronomy, University of Nottingham, Nottingham, United Kingdom

Comparison of post mortem and in vivo MR images requires an understanding of the temperature dependence of the NMR parameters that generate relevant image contrast. Here, we therefore evaluated the temperature dependence of the susceptibility and relaxivity of ferritin-doped agar. A phantom containing cylinders doped with different ferritin concentrations was scanned at 7T at temperatures ranging from 5–35⁰C. R1, R2* and field maps were generated and the variation of each parameter with ferritin concentration was evaluated. The variations of susceptibility, R2* and R1 with ferritin concentration all decreased with increasing temperature with R2* showing the strongest temperature dependence.

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