Abstract #1530

Simultaneous Multi-Angular Relaxometry of Tissue with Magnetic Resonance Imaging (SMART MRI)

Alexander L Sukstanskii¹, Jie Wen¹, Anne H Cross², and Dmitriy A Yablonskiy¹

¹Mallinckrodt Institute of Radiology, Washington University, Saint Louis, MO, United States, ²Neurology, Washington University, Saint Louis, MO, United States

The cross-relaxation effects between “free” and “bound” water affect the gradient recalled echo (GRE) MRI signal and can bias quantitative measurements of tissue relaxation parameters. Herein we have generalized the classical Ernst equation for the GRE signal dependence on sequence parameters (echo and repetition times, flip angle) by accounting for cross-relaxation effects. The derived equation creates a basis for a new technique - Simultaneous Multi-Angular Relaxometry of Tissue with Magnetic Resonance Imaging (SMART MRI). The technique allows simultaneous quantitative measurements of longitudinal and transverse relaxation rates constants and some essential cross-relaxation parameters without utilizing off-resonance magnetization transfer pulses.

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