Simultaneous Multi-Angular Relaxometry of Tissue with Magnetic Resonance Imaging (SMART MRI)
Alexander L Sukstanskii1, Jie Wen1, Anne H Cross2, and Dmitriy A Yablonskiy1
1Mallinckrodt Institute of Radiology, Washington University, Saint Louis, MO, United States, 2Neurology, Washington University, Saint Louis, MO, United States
The cross-relaxation effects between “free” and “bound” water affect the
gradient recalled echo (GRE) MRI signal and can bias quantitative measurements
of tissue relaxation parameters. Herein we have generalized the classical Ernst
equation for the GRE signal dependence on sequence parameters (echo and
repetition times, flip angle) by accounting for cross-relaxation effects. The derived
equation creates a basis for a new technique - Simultaneous Multi-Angular
Relaxometry of Tissue with Magnetic Resonance Imaging
(SMART MRI). The technique allows simultaneous quantitative measurements of
longitudinal and transverse relaxation rates constants and some essential
cross-relaxation parameters without utilizing off-resonance magnetization
transfer pulses.
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