Abstract #1531

Estimation of the Macro-Molecular Proton R1 in Human Brain at 3 and 7 T

Peter van Gelderen¹ and Jeff H Duyn¹

¹Advanced MRI, LFMI NINDS, National Institutes of Health, Bethesda, MD, United States

The longitudinal relaxation rate (R₁) of MRI-invisible macro-molecular protons is an important parameter in the generation of MT and T₁ contrast. Despite this, considerable uncertainty exists about its actual value. To address this MT and inversion recovery experiments were jointly analyzed with a 2-pool model of exchange, and estimates were derived for human brain at 3T and 7T.

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