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Abstract #1531

Estimation of the Macro-Molecular Proton R1 in Human Brain at 3 and 7 T

Peter van Gelderen1 and Jeff H Duyn1

1Advanced MRI, LFMI NINDS, National Institutes of Health, Bethesda, MD, United States

The longitudinal relaxation rate (R1) of MRI-invisible macro-molecular protons is an important parameter in the generation of MT and T1 contrast. Despite this, considerable uncertainty exists about its actual value. To address this MT and inversion recovery experiments were jointly analyzed with a 2-pool model of exchange, and estimates were derived for human brain at 3T and 7T.

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