Abstract #1535

Fast Field-Cycling NMR Relaxometry Extended in the Ultra-Low Field Region: Calibration Method and Acquisition of T1-Dispersion Curves that reach 2.3 µT

Vasileios Zampetoulas¹, Lionel M. Broche¹, and David J. Lurie¹

¹Aberdeen Biomedical Imaging Centre, School of Medicine & Dentistry, University of Aberdeen, Foresterhill, AB25 2ZD, Aberdeen, United Kingdom, Aberdeen, United Kingdom

A graph of T₁ versus magnetic field obtained via Fast Field-Cycling (FFC) NMR relaxometry techniques can be developed into a new diagnostic tool thanks to the information about molecular dynamics that it provides. In this work, a novel method that compensates for the environmental fields acting on an FFC relaxometer is analysed, and applied to acquire measurements in the µT region for the study of much slower molecular motions, that was not previously possible. The results acquired from human cartilage indicate motions occurring in a slow time scale (0.1 to 10 ms), which show promise for clinical studies.

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