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Abstract #1536

Fast and Accurate T2 Mapping from Multi Spin Echo Data Using Bloch-Simulation-Based Reconstruction: Investigation of intra-subject and inter-scan stability and reproducibility

Veronica Cosi1, Akio Ernesto Yoshimoto2, Timothy Shepherd2,3, KAI Tobias Block2,3, Daniel K Sodickson2,3, and Noam Ben-Eliezer2,3

1Department of Specialised, Experimental, and Diagnostic Medicine, University of Bologna, Bologna, Italy, 2Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, United States, 3Center for Advanced Imaging Innovation and Research (CAI2R), New York University School of Medicine, New York, NY, United States

Accurate quantification of T2 values in vivo poses a long-standing challenge, hampered by the inherent bias of fast multi-SE protocols by stimulated and indirect echoes, non-rectangular slice profile and transmit-field inhomogeneities. This bias, moreover, is dependent on the sequence implementation and parameter-set employed, and thus varies between scanners and vendors. We present full stability and reproducibility tests of a recently developed T2 mapping technique – the echo-modulation curve (EMC) algorithm – which uses precise Bloch simulations of the pulse-sequence scheme to deliver the true T2 value of the tissue in a manner that is independent of the parameter-set and scanner being used.

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