Abstract #1548

Quantitative Susceptibility Mapping of the Substantia Nigra in Parkinson’s Disease

Xinxin Zhao¹, Hedi An², Tian Liu³, Nan Shen², Binshi Bo⁴, Zhuwei Zhang⁴, Pengfei Weng⁴, Meining Chen⁴, Mengchao Pei⁴, Yi Wang^3,4, Dongya Huang², and Jianqi Li⁴

¹Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, People's Republic of, ²Dongfang Hospital Neural Medical Affiliated Tongji University, Shanghai, China, People's Republic of, ³Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, ⁴Department of physics, Shanghai Key Laboratory of Magnetic Resonance and Department of Physics, East China Normal University, Shanghai, China, People's Republic of

Quantitative susceptibility mapping (QSM) provides excellent contrast of iron-rich deep nuclei to quantify iron in the brains. Clinicians are interested in using QSM to diagnose PD patients. QSM and R2* values were measured in the whole substantia nigra in patients with PD and healthy controls. The significant difference between PD patients and healthy controls in the substantia nigra was found on QSM but not on R2* mapping.

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