Abstract #1568

QUANTITATIVE 1H MR TISSUE OXIMETRY (QMRO)

Scott C Beeman¹, Joseph JH Ackerman¹, and Joel R Garbow¹

¹Washington University in St. Louis, St. Louis, MO, United States

A direct and non-invasive measure of tissue O₂would be a major advance. O₂ is paramagnetic and can thus, in principle, be quantified with NMR/MRI. However, such measurements are challenged/masked by two competing effects: (i) magnetization transfer between ¹H spins of tissue water and the solid-like macromolecular matrix (e.g., proteins, cell membranes) and (ii) blood flow, which can bring equilibrium-polarized ¹H spins into the interrogated tissue volume. We describe a strategy for mitigating these confounds and quantify the direct relationship between pO₂ and the MR-measured longitudinal relaxation rate constant, R₁.

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